Bacterial tRNA Modification Enzymes: Potential Role in Biology and Virulence
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چکیده
منابع مشابه
Bacterial tRNA Modification Enzymes: Potential Role in Biology and Virulence
Volume 6 • Issue 2 • 1000e105 Biol Med ISSN: 0974-8369 BLM, an open access journal RNA molecules contain four standard nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine (U). Post-transcriptional RNA modifications are present in many types of RNAs including ribosomal RNA (rRNA), messenger RNA (mRNA), transfer RNA (tRNA), and others. These RNA modifications are important for al...
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Transfer RNA (tRNA) is an RNA molecule that carries amino acids to the ribosomes for protein synthesis. These tRNAs function at the peptidyl (P) and aminoacyl (A) binding sites of the ribosome during translation, with each codon being recognized by a specific tRNA. Due to this specificity, tRNA modification is essential for translational efficiency. Many enzymes have been implicated in the modi...
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tRNA modifications are crucial for efficient and accurate protein translation, with defects often linked to disease. There are 7 cytoplasmic tRNA modifications in the yeast Saccharomyces cerevisiae that are formed by an enzyme consisting of a catalytic subunit and an auxiliary protein, 5 of which require only a single subunit in bacteria, and 2 of which are not found in bacteria. These enzymes ...
متن کاملHigh-molecular-weight forms of aminoacyl-tRNA synthetases and tRNA modification enzymes in Escherichia coli.
The presence of high-molecular-weight complexes of aminoacyl-tRNA synthetases in Escherichia coli has been reported (C. L. Harris, J. Bacteriol. 169:2718-2723, 1987). In the current study, Bio-Gel A-5M gel chromatography of 105,000 x g supernatant preparations from E. coli Q13 indicated high molecular weights for both tRNA methylase (300,000) and tRNA sulfurtransferase (450,000). These tRNA mod...
متن کاملRecent progress of structural biology of tRNA processing and modification.
Transfer RNA (tRNA) is a key molecule to decode the genetic information on mRNA to amino aicds (protein), in a ribosome. For tRNA to fulfill its adopter function, tRNA should be processed into the standard length, and be post-transcriptionally modified. This modification step is essential for the tRNA to maintain the canonical L-shaped structure, which is required for the decoding function of t...
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ژورنال
عنوان ژورنال: Biology and Medicine
سال: 2014
ISSN: 0974-8369
DOI: 10.4172/0974-8369.1000e105